Lazio, the Italian Serie A side, has suffered significant injuries to their defensive core recently, leading to concerns about how they will perform on the pitch. The team is currently without several key players, including center-back Giuseppe Simeone and defender Alessandro Puccini, who have both sustained injuries.

The absence of these two players could be detrimental to Lazio's performance. Simeone was expected to be back in action soon after his injury, but it remains unclear when he will return to full strength. If he does not play again, it will likely mean that the team will be without one of its top defenders.

Similarly, Puccini is also set to miss time while he recovers from his injuries. While he may be able to contribute defensively if he is fully recovered, it is unlikely that he will be able to replace the impact that he had on the team last season.

If the team is unable to find a replacement for these injured players, it will be difficult for them to compete at the highest level. They will need to rely on other players to fill the void left by their absence, which may result in a lower overall performance than they would have otherwise achieved.

Overall, the absence of these injured players will have a significant impact on Lazio's defensive performance this season. The team will need to make sure that they can fill the void left by their absent players, or risk falling behind their opponents in the standings.